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책소개

Circulating in China and 158 other countries and areas, the ongoing COVID-19
outbreak has caused devastating mortality and posed a great threat to public
health. However, efforts to identify effectively supportive therapeutic drugs and
treatments has been hampered by our limited understanding of host immune
response for this fatal disease. To characterize the transcriptional signatures of
host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out
transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage
fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of
COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles
to SARS-CoV-2 infection in patients, and highlight the association between
COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1,
CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2
induced activation of apoptosis and P53 signalling pathway in lymphocytes may be
the cause of patients’ lymphopenia. The transcriptome dataset of COVID-19
patients would be a valuable resource for clinical guidance on anti-inflammatory
medication and understanding the molecular mechansims of host response.

목차

제 1편 코로나바이러스 정의
1. 코로나바이러스감염증-19(Covid-19) 정보 7
2. 코로나바이러스 분류 및 특성 9
3. 코로나바이러스 전자현미경 형태 11
4. 코로나바이러스 구조 (Covid-19 Organization) 13
5. 코로나19: 환경에 지속적인 영향을 미칠까? 19
6. 치료법(Therapeutical Method) 22

제 2편 연구논문
Transcriptomic characteristics of bronchoalveolar lavage fluid and
peripheral blood mononuclear cells in COVID-19 patients

1. Introduction 23
2. Materials and methods 24
3. Quantitative transcriptome analysis of BALF and PBMC from
patients 25
4. Functional enrichment analysis of regulated genes 26
5. SARS-CoV-2 infection may cause lymphocyte apoptosis 27
6. Discussion 28
7. Author Contributions 31
8. ORCID 31
9. References 31

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