회원 로그인 창


로그인 메뉴

따끈따끈! 신착 전자책

더보기

콘텐츠 상세보기
심각한 코로나-19 바이러스 환자의 BTK 억제에 대한 연구


SMART
 

심각한 코로나-19 바이러스 환자의 BTK 억제에 대한 연구

Mark Roschewski, Michail S. Lionakis, Jeff P.Sharman, Joseph Roswarski, Andre Goy5,외 저 | 아진

출간일
2020-07-12
파일형태
PDF
용량
13 M
지원 기기
PC
대출현황
보유1, 대출1, 예약중0
콘텐츠 소개
목차
한줄서평

콘텐츠 소개

Patients with severe COVID-19 have a hyperinflammatory immune response
suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates
macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was
administered off-label to 19 patients hospitalized with severe COVID-19 (11 on
supplemental oxygen; 8 on mechanical ventilation), 18 of whom had increasing
oxygen requirements at baseline. Over a 10-14 day treatment course, acalabrutinib
improved oxygenation in a majority of patients, often within 1-3 days, and had no
discernable toxicity. Measures of inflammation ? C-reactive protein and IL-6 ?
normalized quickly in most patients, as did lymphopenia, in correlation with
improved oxygenation. At the end of acalabrutinib treatment, 8/11 (72.7%) patients
in the supplemental oxygen cohort had been discharged on room air, and 4/8 (50%)
patients in the mechanical ventilation cohort had been successfully extubated, with
2/8 (25%) discharged on room air. Ex vivo analysis revealed significantly elevated
BTK activity, as evidenced by autophosphorylation, and increased IL-6 production
in blood monocytes from patients with severe COVID-19 compared with blood
monocytes from healthy volunteers. These results suggest that targeting excessive
host inflammation with a BTK inhibitor is a therapeutic strategy in severe
COVID-19 and has led to a confirmatory international prospective randomized
controlled clinical trial.

목차

제 1편 코로나바이러스 정의
1. 코로나바이러스감염증-19(Covid-19) 정보 7
2. 코로나바이러스 분류 및 특성 9
3. 코로나바이러스 전자현미경 형태 11
4. 코로나바이러스 구조 (Covid-19 Organization) 13
5. 코로나19: 환경에 지속적인 영향을 미칠까? 19
6. 치료법(Therapeutical Method) 22

제 2편 연구논문
Inhibition of Bruton tyrosine kinase in patients with severe
COVID-19

1. Introduction 23
2. RESULTS 24
3. BTK Activation and IL-6 Production in Monocytes from
COVID-19 Patients 25
4. DISCUSSION 26
5. MATERIALS AND METHODS 28
6. Ethical Considerations 29
7. References 30

한줄서평

  • 10
  • 8
  • 6
  • 4
  • 2

(한글 300자이내)
리뷰쓰기
한줄 서평 리스트
평점 한줄 리뷰 작성자 작성일 추천수

등록된 서평이 없습니다.