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• 2023학년도 상반기 전자책 多대출대회 안내
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책소개

The COVID-19 pandemic is progressing worldwide with an alarming death toll.
There is an urgent need for novel therapeutic strategies to combat potentially
fatal complications. Distinctive clinical features of severe COVID-19 include acute
respiratory distress syndrome, neutrophilia, and cytokine storm, along with
severe inflammatory response syndrome or sepsis. Here, we propose the
putative role of enhanced neutrophil infiltration and the release of neutrophil
extracellular traps, complement activation and vascular thrombosis during
necroinflammation in COVID-19. Furthermore, we discuss how neutrophilic
inflammation contributes to the higher mortality of COVID-19 in patients with
underlying co-morbidities such as diabetes and cardiovascular diseases. This
perspective highlights neutrophils as a putative target for the immunopathologic
complications of severely ill COVID-19 patients. Development of the novel
therapeutic strategies targeting neutrophils may help reduce the overall disease
fatality rate of COVID-19.

목차

제 1편 코로나바이러스 정의
1. 코로나바이러스감염증-19(Covid-19) 정보 7
2. 코로나바이러스 분류 및 특성 9
3. 코로나바이러스 전자현미경 형태 11
4. 코로나바이러스 구조 (Covid-19 Organization) 13
5. 코로나19: 환경에 지속적인 영향을 미칠까? 19
6. 치료법(Therapeutical Method) 22

제 2편 연구논문
Neutrophils and Neutrophil Extracellular Traps Drive
Necroinflammation in COVID-19

1. Abstract 23
2. Introduction 23
3. ACE2 and Neutrophils 24
4. SARS-CoV-2, Neutrophils, and Necroinflammation in
COVID-19 24
5. Diabetes, SARS-CoV-2, and Neutrophils 26
6. Cardiovascular Diseases, SARS-CoV-2, and Neutrophils 27
7. Summary and Perspectives 27
8. References 27

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